One good way to do so is through the Red Cross, which is always quick to respond and has sister organizations in most countries to help its work.
The American Red Cross is offering assistance to the Japanese Red Cross following Friday’s magnitude 8.9 earthquake and resulting tsunami that left towns and villages in Japan devastated.
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You can make a donation to the Red Cross and specifically designate that it is to go to Japanese disaster assistance at this site.
You can also designate funds to go to refugee relief in North Africa, a cause near and dear to my heart. This humanitarian crisis, brought on by the brutality of the Libyan regime, has received considerably less attention, but the Red Cross is addressing it. Donate to help in that crisis here.